Thiol Status ELISA (Sulfhydryl)

Oxidative stress, or the production of oxygen-centered free radicals, has been hypothesised as the major source of DNA damage that in turn can lead to altered genetic expression, disease, and aging of humans.
Serum protein thiol levels in blood can be used to research the reduction/oxidation (redox) status in humans, because thiols react readily with oxygen-containing free radicals to form disulfides.
Moreover, research has shown serum thiols may also reflect DNA repair capacity and the possible eventual accumulation of genetic damage, since a key DNA repair enzyme, poly ADP-ribose polymerase (PARP), is thiol/disulfide redox regulated.
Serum protein thiols can possibly be used to research individual aging status. Data from Banne et al. (2003) strongly confirm an important role of oxidative stress in human disease development, and identify serum thiol status as a potential biochemical endpoint useful in the research of aging.

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