-
-
Overview
-
Please contact us at for specific academic pricing.
Background
Tetrahydromagnolol is a major metabolite of magnolol and acts as a peripheral CB2 receptor agonist. Tetrahydromagnolol also acts as an antagonist at GPR55 [1]. Cannabinoid (CB) receptors belong to the G protein-coupled receptor (GPCR) superfamily and are divided into CB1 and CB2. CB1 activation mediates analgesia, stimulation of appetite, and euphoria, among other effects. CB2 receptor activation results in analgesic and antiinflammatory effects. GPR55, a CB-related orphan receptor, is reported to interact with certain CBs [1]. Tetrahydromagnolol is a highly selective peripheral CB2 receptor agonist that is 19-fold more potent than magnolol with EC50 and Ki values of 0.17 μM and 0.42 μM, respectively. Magnolol is a bioactive compound isolated from the bark of Magnolia officinalis that is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. Magnolol behaved as a partial agonist with selectivity for the CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM). In β-arrestin translocation assay, Tetrahydromagnolol inhibited LPI-induced GPR55 activation with KB value of 13.3 μM [1].
-
- Properties
-
Overview
- Home
- Products
- Life Science
- Analytical Chromatography
- Antibodies
- Assay Kits
- Antigens
- Biochemical Reagents
- Biospecimens
- Cell Culture
- Cell Analysis
- Chemicals
- Cloning and Expression
- Collagen
- Nucleic Acid Detection
- Nucleic Acid Extraction
- Enzymes
- Glycan Analysis
- Hydrogels
- Immunohistochemistry (IHC)
- Ion Exchange Resins
- Liposomes
- Microbiology
- Nanoparticles
- Nucleic Acid Electrophoresis
- Nucleic Acid Synthesis
- PCR
- Proteins
- Protein Biochemistry
- Protein Gel Electrophoresis
- Transfection Reagents
- Ubiquitin-Proteasome
- Venoms
- Lab Solutions
- Amerigo Scientific Instrument
- 3D Bioprinting
- Medical Devices
- Life Science
- Services
- About Us
- Contact Us
.
