Name: Tenovin-3
Price: 452.00 USD

- Overview
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    Background
    
    Tenovin SAR Studies Aimed at Increasing Water Solubility
    
    ID
    
    p53 Increasea
    K40Ac Tubulin Increaseb
    SirT2 Inhibitionc
    
    R1
    R2
    
    Tenovin-1
    tBu
    NHCOCH3
    +
    +
    +
    
    Tenovin-2
    tBu
    NHCOCH(CH3)2
    +
    +
    +
    
    Tenovin-3
    tBu
    NH2
    +
    +
    +
    
    Tenovin-4
    N3
    NHCOCH3
    −
    −
    −
    
    Tenovin-5
    tBu
    NHCOPh
    +
    +
    +
    
    Tenovin-6
    tBu
    NHCO(CH2)4NMe2.HCl
    +
    +
    +
    
    a Ability to increase p53 levels was determined in MCF-7 cells treated for 6 hr at 10 μM.
    b Ability to increase K40 Ac-tubulin levels was determined in H1299 cells treated
    c SirT2 inhibition assessed using a compound concentration of 10 or 30 μM depending on the compound's solubility in the assay buffer.
- Properties
  - Categories
    
    p53 activator
    
    Alternative Name
    
    Tenovin 3;Tenovin3; N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide
    
    CAS Number
    
    1011301-27-1
    
    Molecular Formula
    
    C18H21N3OS
    
    Molecular Weight
    
    327.44
    
    Appearance
    
    A solid
    
    Purity
    
    99.85%
    
    Solubility
    
    insoluble in H2O; ≥14.45 mg/mL in DMSO; ≥2.88 mg/mL in EtOH with gentle warming
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)N
    
    * For Research Use Only