Name: Temsirolimus
Price: 232.00 USD

- Overview
  - Temsirolimus is a semisynthetic macrocyclic lactone prepared from Rapamycin. It is a dihydroxymethyl propionic acid ester and analog of Rapamycin. The compound is prepared by selective acylation of the 42-hydroxy group with a protected bis (dihydromethyl) propionic acid, followed by deprotection.
    Temsirolimus is an antiproliferative and antiangiogenic mTOR inhibitor. mTOR protein has a role in integrating environmental signals that affect cell growth and proliferation. It has anti-neoplastic properties and immune-modulating activity. It can be used in kinase phosphatase biology research.
    Temsirolimus is soluble in ethanol, methanol, DMF and DMSO.
    
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    Background
    
    Temsirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins.
- Properties
  - CAS Number
    
    162635-04-3
    
    Molecular Formula
    
    C56H87NO16
    
    Molecular Weight
    
    1030.3
    
    Appearance
    
    White solid
    
    Other Properties
    
    Source: semi-synthetic
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Temsirolimus can be used in renal-cell carcinoma (RCC). The rationale for using mTOR inhibitors to treat malignancies has focused on the direct, growth-inhibitory effects.
    It is surprising that Temsirolimus can enhance anti-tumor immunity. In an expimental murine model of RCC (RENCA), the combination of an HSP-based cancer vaccine and Temsirolimus was more effective against tumors than either agent alone. In animal models of tumor vaccines, Temsirolimus enhanced vaccine activity by enhancing effector T-cell function and enhancing production of CD8 memory T cells (Wang et al, 2011).
    Temsirolimus can induce antiproliferative effects by inhibiting mTOR in Bel-7402 liver cancer cells. Viability tests, and flow cytometry was used to analyze cell cycle after treatment. It can inhibit mTOR signaling and proliferation in vitro, for a promising strategy for liver cancer (Li et al, 2013).