Name: TCS PIM-1 1
Price: 276.00 USD

- Overview
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    Background
    
    TCS PIM-1 1 is a selective inhibitor of Pim-1 with IC50 value of 50 nM [1].
    Pim-1 is a proto-oncogene serine/threonine-protein kinase and plays an important role in cell cycle progression, apoptosis, transcriptional activation and more general signal transduction pathways. It has been shown that Pim-1 over-expression is correlated with a variety of human cancers [2].
    TCS PIM-1 1 is a potent Pim-1 inhibitor and has a better selectivity to Pim-1 than to Pim-2. It was revealed that TCS PIM-1 1 was the most potent inhibitor of Pim-1 by outlining the crystal structure and it was also shown that TCS PIM-1 1 had better inhibitory activity to Pim-1 compared with Pim-2 [1].
    
    [1]. Cheney, I.W., et al., Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett, 2007. 17(6): p. 1679-83.
    [2]. Cen, B., et al., The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol, 2014. 34(13): p. 2517-32.
- Properties
  - Alternative Name
    
    6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile
    
    CAS Number
    
    491871-58-0
    
    Molecular Formula
    
    C18H11BrN2O2
    
    Molecular Weight
    
    367.2
    
    Appearance
    
    A solid
    
    Purity
    
    98.52%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥12.8 mg/mL in DMSO
    
    Storage
    
    Store at 4°C
    
    * For Research Use Only

TCS PIM-1 1

TCS PIM-1 1

Background

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