Name: TC-E 5003
Price: 236.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    TC-E 5003 is a selective inhibitor of PRMT1 with IC50 value of 1.5 μM [1].PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family and plays a pivotal role in many biological processes by post-translational modification of target proteins. It has been reported that PRMT1 abnormal expression was observed in many types of cancer and its inhibitors was regarded as promising target in clinic [2].TC-E 5003 is a potent PRMT1 inhibitor. When tested with breast cancer cell line MCF7a or prostate cancer cell line LNCaP, TC-E treatment induced cell apoptosis and inhibited cell proliferation by functioning on PRMT1. And it also reported that TC-E treatment attenuated androgen-induced gene expression in LNCaP cells [1].
    
    [1]. Bissinger, E.M., et al., Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem, 2011. 19(12): p. 3717-31.
    [2]. Avasarala, S., et al., PRMT1 is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-Small Cell Lung Cancer. J Biol Chem, 2015.
- Properties
  - Alternative Name
    
    N,N'-(sulfonylbis(4,1-phenylene))bis(2-chloroacetamide)
    
    CAS Number
    
    17328-16-4
    
    Molecular Formula
    
    C16H14Cl2N2O4S
    
    Molecular Weight
    
    401.26
    
    Appearance
    
    Off-white solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥49 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Qi Zhu, Dinghui Wang, et al. "Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ." J Biol Chem. 2022 Jul 31;102309. PMID: 35921899

TC-E 5003

TC-E 5003

Background

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