TAK-700 (Orteronel)

TAK-700 (Orteronel)

Catalog Number:
L002369128APE
Mfr. No.:
APE-A4326
Price:
$283
  • Size:
    5mg
    Quantity:
    Add to Cart:
      • Overview
        • Please contact us at for specific academic pricing.

          Background

          TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3.

      • Properties
        • Alternative Name
          6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide
          CAS Number
          426219-18-3
          Molecular Formula
          C18H17N3O2
          Molecular Weight
          307.35
          Appearance
          A solid
          Purity
          98.00%
          Solubility
          insoluble in H2O; ≥11.2 mg/mL in DMSO; ≥11.93 mg/mL in EtOH with ultrasonic
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference
        • 1. Guengerich FP, Wilkey CJ, et al. "Conformational selection dominates binding of steroids to human cytochrome P450 17A1." J Biol Chem. 2019 Jun 28;294(26):10028-10041. PMID:31072872
          2. Gonzalez E, Guengerich FP. "Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1." J Biol Chem. 2017 Jul 6. pii: jbc.M117.794917. PMID:28684414
          3. F. Peter Guengerich,Martin Egli,et al."The Kinetic and Chemical Mechanisms of Human Cytochrome P450 17A1." Vanderbilt University. 2017 May.

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