Name: TAB1 Polyclonal Antibody
Price: 347.00 USD

Overview
- Please contact us at for specific academic pricing.
  
  Background
  
  The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Properties
- Host
  
  rabbit
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Recombinant fusion protein of human TAB1 (NP_006107.1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1 mg/mL
  
  Antigen
  
  TAB1, 3'-Tab1, MAP3K7IP1 (Gene ID:10454; UniProt:Q15750)
  
  * For reference only.

Applications

Application

IF

Application	Dilutions
IF	1:10-1:100

TAB1 Polyclonal Antibody

TAB1 Polyclonal Antibody

Background

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