Superoxide Dismutase (SOD) Activity Assay (Colorimetric)

Superoxide Dismutases (SODs, EC1.15.1.1) are enzymes which detoxify superoxide anions (O2-) by converting (dismutating) them into two less damaging species: oxygen (O2) and hydrogen peroxide (H2O2). The dismutation reaction occurs in nearly all cells as an important antioxidant mechanism in response to O2- exposure to protect against its toxicity. There are three major families of superoxide dismutases, which are classified based on their metal cofactor: Cu/Zn, Fe/Mn, and Ni. The major intracellular SOD is a 32-kD copper and zinc containing homodimer (Cu/Zn SOD). Abnormal activities of SODs are associated with different health disorders such as familial Amyotrophic Lateral Sclerosis (ALS), perinatal lethality, neural disorders, downs syndrome, thyroid dysfunction and cancer.

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