Sulfachloropyridazine

Sulfachloropyridazine

Catalog Number:
M001341873TOK
Mfr. No.:
TOK-S118
Price:
$206
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      • Overview
        • Sulfachloropyridazine is a broad-spectrum sulfonamide antibiotic that can be used for bacteria causing urinary tract infections. It is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA) which is required for bacterial folic acid synthesis. It is frequently used in veterinary research, and has been found to bolster the immune system in plants.

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          Background

          Sulfachloropyridazine inhibits the enzyme dihydropteroate synthase, thereby blocking dihydrofolic acid synthesis.

      • Properties
        • CAS Number
          80-32-0
          Molecular Formula
          C10H9ClN4O2S
          Molecular Weight
          284.72
          Appearance
          Off-white to light yellow powder
          Solubility
          Water (7 mg/mL). Soluble in methanol, 0.5 M NaOH, and DMSO
          Other Properties
          Source: bacterium derived from. Can also be semi-synthetic, synthetic
          Storage
          2-8°C

          * For research use only

      • Applications
        • Application Description
          Spectrum: broad-spectrum, effective against Gram-positive and Gram-negative bacteria. Also effective for Mycoplasma.

          Microbiology Applications: Sulfachloropyridazine can be used to study metabolic pathways, reaction kinetics, and toxicity profiles.

          Plant Biology Applications: High-throughput screening of Arabidopsis plant suspensions were used to screen libraries of bioactive molecules and natural products for plant activators (agrochemicals that activate the plant immune system and protect crops from disease). Sulfachlorpyridazine was found to be a candidate that increased disease resistance, using Pseudomonas syringae pv. tomato. (Noutoshi et al, 2012).

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