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Overview
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Background
SUFU encodes a component of the Sonic hedgehog (SHH;MIM 600725)/Patched (PTCH;MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e. g. , HPE3, MIM 142945;BCNS, MIM 109400;and GCPS, MIM 175700).
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Overview