Name: SU6656
Price: 241.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    SU6656 is a small-molecule, potent and selective inhibitor of Src tyrosine kinases.
    Src (proto-oncogene tyrosine-protein kinase) is a non-receptor protein tyrosine kinase family including 9 members and promotes survival, angiogenesis, and proliferation and invasion pathways.
    In NIH 3T3 cell, SU6656 inhibits PDGF-/Src-driven mitogenesis and PDGF-stimulated c-Myc induction. [1] In UT-7/TPO, SU6656 cause ceased cell division but DNA continues accumulating by endomitosis. It also increased CD41 and CD61 expression on the cell surface in. [2] SU6656 in combination with radiation decrease clonogenic survival of endothelial cells. Src family kinase inhibition by SU6656 attenuated radiation-induced Akt phosphorylation and increased radiation-induced apoptosis and vascular endothelium destruction. [3]
    In vivo, SU6656 administered prior to irradiation significantly promotes radiation-induced destruction of blood vessels within the tumor windows. It also facilitates tumor growth delay when administered during fractionated irradiation. [3]
    
    1. Blake RA, Broome MA, Liu X et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20(23):9018-27.
    2. Lannutti BJ, Blake N, Gandhi MJ et al. Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656. Blood. 2005 May 15;105(10):3875-8.
    3. Cuneo KC, Geng L, Tan J et al. SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation. Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1197-203.
- Properties
  - Alternative Name
    
    (Z)-2-hydroxy-N,N-dimethyl-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-3H-indole-5-sulfonamide
    
    CAS Number
    
    330161-87-0
    
    Molecular Formula
    
    C19H21N3O3S
    
    Molecular Weight
    
    371.45
    
    Appearance
    
    A solid
    
    Purity
    
    98.17%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥18.55 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Tian Y, Guo H, et al. "Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress." Cell Death Dis. 2020;11(5):319. PMID:32371936

SU6656

SU6656

Background

We Also Recommend

AMG-47A

FTI 277 HCl

SAR191801