Name: Stiripentol
Price: 180.00 USD

- Overview
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    Background
    
    Stiripentol is an LDH inhibitor. It is a new-generation antiepileptic drug, and its chemical structure is unrelated to other antiepileptic drugs. Seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase (LDH), which is a component of the astrocyte-neuron lactate shuttle [1].Stiripentol is used for the treatment of Dravet syndrome, a rare form of epilepsy (26). Stiripentol (300 mg/kg ip) had a small effect on high-voltage spikes in the kainate model. Stiripentol (500 mM) inhibited the lactate-to-pyruvate conversion as well as the pyruvate-to-lactate conversion by both human LDHs. Lineweaver-Burk plots revealed that the inhibition by stiripentol was noncompetitive, suggesting that stiripentol binds to the LDHs at a different site with lactate and pyruvate. [1]
    
    [1]. Sada N, Lee S2, Katsu T et al. Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science. 2015 Mar 20;347(6228):1362-7.
- Properties
  - Alternative Name
    
    (E)-1-(benzo[d][1,3]dioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
    
    CAS Number
    
    49763-96-4
    
    Molecular Formula
    
    C14H18O3
    
    Molecular Weight
    
    234.29
    
    Appearance
    
    A colorless liquid
    
    Purity
    
    99.48%
    
    Solubility
    
    insoluble in H2O; ≥46.7 mg/mL in EtOH; ≥9.9 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Stiripentol

Stiripentol

Background

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