Name: STF 31
Price: 260.00 USD

- Overview
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    Background
    
    STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μΜ [1].
    The inactivated von Hippel-Lindau (VHL) tumor suppressor gene drives renal cell carcinomas (RCCs) development, which imparts the reliance on the GLUT1 and aerobic glycolysis. Compounds of the 3-series, exemplified by STF-31, selectively kills RCCs by specifically targeting glucose uptake through GLU1, on which is the unique dependence of these cells for survival.
    STF-31 (0.01-10 μΜ; 10 days) is specifically toxic to RCC4 cells without VHL, while wild-type RCC4 cells (RCC4/VHL) are relatively unaffected. Wild-type RCC4 cells treated with STF-31 (5 μΜ; 10 days) largely recovery, while RCC4 cells dose not on the same condition. No evidence proved the drug-induced cells autophagy, apoptosis, or DNA damages, but wild-type RCC4 cells underwent necrotic cell death in response to STF-31 by the ability of the cells to exclude trypan blue [1].
    Soluble analog of STF-31 (11.6 mg/kg; i.p.) treatment delayed tumor growth in mice with VHL-deficient RCC tumor xenografts [1]. STF-31 (10 mg/kg; i.p.; twice daily for 2 days, followed by once daily for another 3 days) did not affect normal mice body weight, behavior and Scotopic electroretinography (ERG) responses. STF-31 reduced light-induced CX3CR1gfp/+ mice microglial activation and retinal degeneration [2].
    
    [1] Chan D A, Sutphin P D, Nguyen P, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011, 3(94): 94ra70.
    [2] Wang L X, Pavlou S, Du X, et al. Glucose transporter 1 critically controls microglial activation through facilitating glycolysis. Mol Neurodegener. 2019, 14(1): 2.
- Properties
  - Alternative Name
    
    4-((4-(tert-butyl)phenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide
    
    CAS Number
    
    724741-75-7
    
    Molecular Formula
    
    C23H25N3O3S
    
    Molecular Weight
    
    423.53
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥42.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Store at RT
    
    * For Research Use Only

STF 31

STF 31

Background

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