Name: STAT3 Polyclonal Antibody (1 mg/mL) for IF
Price: 347.00 USD

Overview
- Please contact us at for specific academic pricing.
  
  Background
  
  The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Properties
- Host
  
  rabbit
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Recombinant fusion protein of human STAT3 (NP_644805.1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1 mg/mL
  
  Antigen
  
  ADMIO, ADMIO1, APRF, HIES, STAT3, Stat3 (Gene ID:6774; UniProt:P40763)
  
  * For reference only.

Applications

Application

IF

Application	Dilutions
IF	1:50-1:200

STAT3 Polyclonal Antibody (1 mg/mL) for IF

STAT3 Polyclonal Antibody (1 mg/mL) for IF

Background

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