Name: st-Ht31
Price: 298.00 USD

- Overview
  - AKAP-PKA interaction inhibitor.
    st-Ht31 is a stearated and cell-permeable version of the peptide Ht-31, which inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP). The sequence of st-Ht31 is derived from human thyroid RII anchoring protein Ht31, comprising residues 493-515, and is the minimum region of Ht 31 required for RII binding. Disruption of the AKAP-PKA interaction by st-Ht31 alters human airway smooth muscle proliferation and enhances contractile force generation with upregulation of the contractile protein ?-sm-actin. st-Ht31 also increases cytosolic PKA activity and is able to reverse foam cell formation and restore metabolic health in otherwise dysfunctional macrophages.
    
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- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Alternative Name
    
    S-Ht31, st-Ht 31 (493-515)
    
    Molecular Formula
    
    C129H217N29O39
    
    Molecular Weight
    
    2798.27
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble to 1 mg/ml in 0.01M PBS
    
    Other Properties
    
    Sequence: Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH,Stearyl-DLIEEAASRIVDAVIEQVKAAGAY
    Modification: N-terminal stearyl
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

st-Ht31

st-Ht31

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