Name: ST 2825
Price: 779.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    ST 2825 is a specific inhibitor of MyD88 dimerization [1].
    ST 2825 is a synthetic compound which mimics the structure of the heptapeptide in the BB-loop of the MyD88-TIR domain and interferes the homodimerization of MyD88. ST 2825 was proved to specifically inhibit the homodimerization of MyD88 TIR domains without affecting the homodimerization of death domains. In HEK293T cells transfected with Flag-MyD88 and Myc-MyD88, ST 2825 inhibited the interaction of the two MyD88 by 80% at the concentration of 10 μM. This inhibition resulted in the subsequent interference of the IRAK1 and IRAK4 recruitment. Besides that, administration of ST 2825 significantly inhibited the IL-6 production stimulated by IL-1β at doses of 100 and 200 mg/kg in mice. Furthermore, 8 μM ST 2825 completely blocked the TLR9-induced B cell proliferation. ST2825 also suppressed the generation of plasma cells induced by CpG dose-dependently [1].
    
    [1] Loiarro M, Capolunghi F, Fantò N, et al. Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. Journal of leukocyte biology, 2007, 82(4): 801-810.
- Properties
  - Alternative Name
    
    ST2825;ST-2825; (4R,7R,8aR)-1'-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]-6-oxospiro[3,4,8,8a-tetrahydro-2H-pyrrolo[2,1-b][1,3]thiazine-7,2'-pyrrolidine]-4-carboxamide
    
    CAS Number
    
    894787-30-5
    
    Molecular Formula
    
    C27H28Cl2N4O5S
    
    Molecular Weight
    
    591.51
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Alyson B. Barnes, Rachel M. Keener, et al. "Human genetic diversity regulating the TLR10/TLR1/TLR6 locus confers increased cytokines in response to Chlamydia trachomatis." HGG Adv. 2021 Nov 25;3(1):100071. PMID:35047856
    2. Zhao C, Zhou J, et al. "DHA Sensor GPR120 in Host Defense Exhibits the Dual Characteristics of Regulating Dendritic Cell Function and Skewing the Balance of Th17/Tregs." Int J Biol Sci. 2020 Jan 1;16(3):374-387. PMID:32015675
    3. Pantaleão L, Rocha GHO, et al. "Connections of annexin A1 and translocator protein-18 kDa on toll like receptor stimulated BV-2 cells." Exp Cell Res. 2018 Jun 15;367(2):282-290. PMID:29649428
    4. Janda J, Burkett NB, et al. "Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin." Photochem Photobiol. 2016 Nov;92(6):816-825. PMID:27859308
    5. Wang SH, Wang SC, et al. "Induction of cyclooxygenase-2 gene by Candida albicans through EGFR, ERK, and p38 pathways in human urinary epithelium." Med Mycol. 2016 Sep 23. PMID:27664170
    6. Hu LT, et al. "Role of TREM-1 in response to Aspergillus fumigatus infection in corneal epithelial cells.." Int Immunopharmacol.2014 Sep 18. pii:S1567-5769(14)00363-4. PMID:25242387

ST 2825

ST 2825

Background

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