Name: SRPK2 Polyclonal Antibody (1.56 mg/mL) for IHC, ELISA
Price: 253.00 USD

Overview
- Gene Accession: BC035214
  
  Please contact us at for specific academic pricing.
  
  Background
  
  Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Fusion protein of human SRPK2
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1.56 mg/mL
  
  Antigen
  
  Human serine kinase SRPK2 mRNA, complete cds, Serine kinase SRPK2, Serine/arginine rich protein specific kinase 2, Serine/arginine-rich protein-specific kinase 2, Serine/threonine protein kinase SRPK2 , SFRS protein kinase 2, SFRSK2 , SR protein specific kinase 2, SR-protein-specific kinase 2, SRPK2, SRPK2, SRSF protein kinase 2 C-terminal (UniProt:P78362)
  
  * For reference only.

Applications

Application

IHC; ELISA

Application	Dilutions
IHC	1:100-1:300
ELISA	1:5000-1:10000

SRPK2 Polyclonal Antibody (1.56 mg/mL) for IHC, ELISA

SRPK2 Polyclonal Antibody (1.56 mg/mL) for IHC, ELISA

Background

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