Spinosyn A

- Overview
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    Background
    
    Spinosyn A is an insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide.The spinosyns are a family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa. Spinosyn A is identified as a naturally-occurring macrocyclic lactone that is a potent insecticide.In vitro: The mixture of spinosyns A and D, a commercial insecticide TracerTM (DowAgroSciences), is useful against various crop pests such as tobacco budworm. It was found that the deoxy analogs of spinosyns A were more potent insecticides than their respective parent factor. Moreover, the 2’-desmethoxy analogs of spinosyns A showed insecticidal potency against H. virescens greater than that of spinosyns A and D, suggesting that polarity was not well tolerated. Furthermore, the activity of 3'-deoxy spinosyn J was about the same as spinosyn A, and the activity of 2'-deoxy spinosyn H was found to be slightly greater than that of spinosyn A [1].In vivo: Currently, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Categories
    
    insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide
    
    Alternative Name
    
    A-83543A|Lepicidin A; (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3,
    
    CAS Number
    
    131929-60-7
    
    Molecular Formula
    
    C41H65NO10
    
    Molecular Weight
    
    732.0
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN(C)[[email protected]]1CC[[email protected]@](O[[email protected]]([[email protected]@H](C)C2=O)CCC[[email protected]](CC)OC(C[[email protected]]3([H])C2=C[[email protected]]4([H])[[email protected]@]3([H])C=C[[email protected]@]5([H])[[email protected]@]4([H])C[[email protected]](O[[email protected]]6([H])O[[email protected]@H](C)[[email protected]](OC)[[email protected]@H](OC)[[email protected]]6OC)C5)=O)([H])O[[email protected]@H]1C
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Spinosyn A

Background

Documents

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