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Overview
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Sophocarpine monohydrate, a natural product found in Sophora alopecuroides, has a wide range of pharmacological effects (anti-viral, anti-tumor, anti-inflammatory). Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM.
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Overview