Name: sodium 4-pentynoate
Price: 247.00 USD

- Overview
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    Background
    
    Sodium 4-pentynoate is an alkynylacetate analogue, which could be incorporated with cellular proteins and utilized as chemical reporter for the profiling of acetylated proteins [1].
    Reversible protein acetylation is generally regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), which play important roles in regulating gene expression and occurrence of disease [1].
    The p300-KAT-catalyzed acetylation with histone protein H3 showed that the the 4-pentynoate group can be efficiently transferred onto lysine residue. In jurkat cells, metabolic labeling of sodium 4-pentynoate was in time and dose dependent, which was optimal at 2.5-10 μM of acetate analogs for 6-8 hr. Fluorescent profiling identified 194 of 4-pentynoate labeled proteins from jurkat cells, where 86% of them were identified by radioactive method and 14% was newly identified [1].
    
    Reference:[1]. Yang Y Y, et al. Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc., 2010, 132(11): 3640-3641.
- Properties
  - Categories
    
    chemical reporter for the profiling of acetylated proteins
    
    Alternative Name
    
    sodium pent-4-ynoate
    
    CAS Number
    
    101917-30-0
    
    Molecular Formula
    
    C5H5NaO2
    
    Molecular Weight
    
    120.08
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C#CCCC(=O)[O-].[Na+]
    
    * For Research Use Only