Name: SKI II
Price: 196.00 USD

- Overview
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    Background
    
    SKI II is an inhibitor of sphingosine kinase with IC50 value of 0.5μM[1].
    SKI II is selective against SK and has no inhibition of human protein kinases ERK2, PKC-I and the lipid kinase PI3K. It is reported that SKI II is not a competitive inhibitor at the ATP-binding site of SK. SKI II also inhibits endogenous SK in intact MDA-MB-231 cells [1].
    As a SK inhibitor, SKI II prevents SK from catalyzing the generation of sphingosine 1-phosphate (S1P). The blockage of S1P formation leads to inhibition of proliferation, as well as the induction of apoptosis in cancer cells. SKI II shows cytotoxicity in T-24 human bladder carcinoma cells, MCF-7 human breast adenocarcinoma cells and the subline of MCF-7 cells, MCF-7/VP, with IC50 values of 4.6μM, 1.2μM and 0.9μM, respectively [1].
    
    [1] French KJ, Schrecengost RS, Lee BD, Zhuang Y, Smith SN, Eberly JL, Yun JK, Smith CD. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9.
- Properties
  - Alternative Name
    
    4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
    
    CAS Number
    
    312636-16-1
    
    Molecular Formula
    
    C15H11ClN2OS
    
    Molecular Weight
    
    302.78
    
    Appearance
    
    A solid
    
    Purity
    
    98.83%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥15.15 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

SKI II

SKI II

Background

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