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Overview
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Please contact us at for specific academic pricing.
Background
SKF 81297 hydrobromide is a selective agonist of the dopamine D1-like receptor, with a Ki value of 1.9 nM. The dopamine D1-like receptors, consisting of D1 and D5 subtypes, are a subfamily of dopamine receptors that mediate excitatory neurotransmission after binding the endogenous neurotransmitter dopamine. The dopamine D1-like receptors have been implicated in dopaminergic regulation of a variety of fundamental neurophysiologic processes including mood, motivation, cognitive function, as well as motor activity.
1. Neumeyer JL, Kula NS, Bergman J, Baldessarini RJ. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. European Journal of Pharmacology, 2003, 474(2-3): 137-140.
2. Undieh AS. Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacology & Therapeutics, 2010, 128(1): 37-60.
3. Vermeulen RJ, Drukarch B, Sahadat MC, et al. The dopamine D1 agonist SKF 81297 and the dopamine D2 agonist LY 171555 act synergistically to stimulate motor behavior of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinsonian rhesus monkeys. Movement Disorders, 1994, 9(6): 664-672.
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