SID 26681509

SID 26681509

Catalog Number:
L002369204APE
Mfr. No.:
APE-A4424
Price:
$543
  • Size:
    Quantity:
    Add to Cart:
      • Overview
        • Please contact us at for specific academic pricing.

          Background

          IC50: 56 nMSID 26681509 is a potent and reversible human cathepsin L inhibitor.The cathepsins have been found to comprise a family of lysosomal protease enzymes whose primary functions, such as protein degradation, play a keyl role in normal cellular homeostasis. Overexpression of cathepsin L and/or abnormal activity has been implicated in a number of disease states.In vitro: SID 26681509 was found to inhibit human cathepsin L with an IC50 of 56 nM. After preincubation with enzyme for 1, 2, and 4 h before substrate addition, SID 26681509 showed increasing potency, with IC50 values falling to 7.5, 4.2, and 1.0 nM, respectively, indicating a slow onset of inhibition. SID 26681509 was also observed to be nontoxic to human aortic endothelial cells up to 100 μM. SID 26681509 was active in an in vitro propagation assay against P. falciparum with an IC50 of 15.4 μM. Additionally, the thiocarbazate inhibitor was toxic toward L. major promastigotes with an IC50 of 12.5 μM [1]. In vivo: SID 26681509 showed a lack of toxicity to zebrafish in a live organism assay at 100 μM [1].Clinical trial: N/A

      • Properties
        • Alternative Name
          (S)-S-(2-((2-ethylphenyl)amino)-2-oxoethyl) 2-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoyl)hydrazinecarbothioate
          CAS Number
          958772-66-2
          Molecular Formula
          C27H33N5O5S
          Molecular Weight
          539.65
          Appearance
          White solid
          Purity
          98.00%
          Solubility
          <26.98mg/ml in DMSO; <5.4mg/ml in ethanol
          Storage
          Store at -20°C

          * For Research Use Only

    Note: If you don't receive our verification email, do the following:

    Copyright © Amerigo Scientific. All rights reserved.