SiaFind Alpha 2,3-Specific Lectenz® Kit

Lectenz® are a novel class of lectin-like, enzyme-derived glycan-targeting affinity reagents engineered by computationally-guided directed evolution. The reagents are highly purified recombinant proteins, each designed to bind a specific glycan structure, and have advantages over naturally occurring lectins in rapid detection and enrichment of glycoconjugates.

SiaFind™ α2,3-Specific Lectenz® Kits contain a sialic acid affinity reagent for the detection, separation, or enrichment of sialoglycans terminating in Neu5Acα2,3Gal commonly found in glycoconjugates (glycoproteins, glycolipids, and oligo- or polysaccharides). It has high affinity and specificity towards α2,3 linked sialic acids on glycans. However, it does not bind effectively to branched sialylated epitopes such as sialyl Lewis A/X. Each kit also includes a 5X binding buffer to ensure maximum reagent specificity and ease of use.

Each SiaFind™ Lectenz® has a molecular mass of about 77 kD and works as a monomer without bivalent metal ions. They are 6xHis-tagged proteins and an anti-polyhistidine antibody, or in the case of the biotinylated version, a streptavidin conjugate can be used for detection. The fluorescent version can be directly detected.

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