Name: Sclareolide
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Target: NpABC1IC50: NASclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco [1]. Sclareolide is a close analog of sclareol, an antifungal diterpene produced at the leaf surface of Nicotiana spp. Moreover, Sclareolide is used as a fragrance in cosmetics and has been more recently marketed as a weight loss supplement.In vitro: Sclareolide (20, 100, and 500 μM) dose-dependently induced NpABC1 expression of a plasma membrane protein in Nicotiana plumbaginifolia cells [1]. Sclareolide (20 μM) had no effect on Nicotiana plumbaginifolia cell growth although the induction of NpABC1 expression. In addition, NpABC1 transcript levels were high 3 hr after sclareolide addition and then decreased. However, the level of NpABC1 protein expression remained fairly stable for up to 12 hr [1]. The 160-kD NpABC1 protein is localized in the plasma membrane and is involved in the secretion of a secondary metabolite which plays an important role in plant defense [1].In vivo: N/A
    
    Reference:1. Jasinski M, Stukkens Y, Degand H, Purnelle B, Marchand-Brynaert J, Boutry M. A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion. Plant Cell. 2001;13(5):1095-107.
- Properties
  - Categories
    
    Sesquiterpene lactone natural product
    
    Alternative Name
    
    (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(3aH)-one
    
    CAS Number
    
    564-20-5
    
    Molecular Formula
    
    C16H26O2
    
    Molecular Weight
    
    250.38
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(CCC[[email protected]@]1([[email protected]@]2([H])CC(O3)=O)C)([[email protected]]1([H])CC[[email protected]]23C)C
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Sclareolide

Sclareolide

Background

Documents

We Also Recommend

Diosmetin

Troxerutin

Xanthone