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SCH900776 S-isomer

SCH900776 S-isomer

Catalog Number:

L002368869APE

Mfr. No.:

APE-A3806

Price:

$303

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- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM). SCH900776 exposure phenocopies short interfering RNA-mediated CHK1 ablation and interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in tumor cell backgrounds. Chk1 inhibitor SCH 900776 abrogates cytarabine-induced S-phase arrest and enhances cytarabine cytotoxicity in acute leukemia cell lines and leukemic blasts in vitro.
- Properties
  - Alternative Name
    
    SCH 900776 S-isomer;SCH-900776 S-isomer; (S)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
    
    CAS Number
    
    891494-64-7
    
    Molecular Formula
    
    C15H18BrN7
    
    Molecular Weight
    
    376.25
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥37.6 mg/mL in DMSO; insoluble in H2O; ≥47.8 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    NC1=C(Br)C([C@@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
    
    * For Research Use Only

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