Name: SB742457
Price: 316.00 USD

- Overview
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    Background
    
    SB742457 is a selective antagonist of 5-HT6 receptor with a pKi value of 9.63 [1].SB742457 has been found to be a highly selective 5-HT6 receptor antagonist with high affinity to human 5-HT6 receptor. The pKi value of SB742457 is 9.63. In addition, because of the orally bioavailable, SB742457 has been reported to promote brain penetration in rat over previously developed compounds. Besides, subchronic daily oral pre-dosing of SB742457 (1.5mg/kg) has been noted to significantly induce by the cholinergic antagonist scopolamine (0.5mg/kg) in a novel object recognition paradigm. Apart from these, acute oral treatment of SB742457 has been found to induce significant increases levels of glutamate and acetylcholine in extracellular in the medial prefrontal cortex of freely moving rats [1].
- Properties
  - Categories
    
    5-HT6 receptor antagonist, highly selective and high affinity
    
    Alternative Name
    
    3-(benzenesulfonyl)-8-piperazin-1-ylquinoline
    
    CAS Number
    
    607742-69-8
    
    Molecular Formula
    
    C19H19N3O2S
    
    Molecular Weight
    
    353.44
    
    Appearance
    
    A solid
    
    Purity
    
    99.46%
    
    Solubility
    
    insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4
    
    * For Research Use Only