SARS-CoV-2 Pseudovirus, Delta plus variant, B.1.617.2.1

The Delta Plus Variant also called B.1.617.2.1 is Delta variant with an additional K417 N mutation in Spike protein. It was identified in India in the spring of 2021.
Spike protein mutations: T19R, G142D, Δ156/157, R158G, K417N, L452R, T478K, D614G, P681R, D950N

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Background

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a single-stranded RNA virus with a genome of around 30 kb and 29 proteins. The virus has six major open reading frames (ORFs) including ORF1a, ORF1b, spike (S), envelope (E), membrane (M) and nucleocapsid (N), as well as several accessory ORFs. Four conserved structural proteins are encoded by the S, E, M, and N ORFs. The M protein is the most abundant transmembrane protein and plays a central role in viral assembly and morphology. The E protein is also one of the main structural proteins and is involved in multiple processes of the virus life including virus assembly, release, and ion channel activity processing. The N protein an abundant RNA-binding protein that plays a crucial role in various vital activities after virus invasion including viral replication, transcription processes, and genome assembly. The S glycoproteins are homotrimers, with each monomer containing two subunits (S1 and S2). S1 contains an N-terminal domain (NTD) and a receptor-binding domain (RBD), and the domains recognize and bind the angiotensin-converting enzyme 2 (ACE-2) receptor required for viral attachment and entry into host cells. S2 has multiple domains that mediate membrane fusion between the viral envelope and the host cell.