Name: Santacruzamate A (CAY10683)
Price: 196.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Santacruzamate A (CAY10683) is a potent and selective inhibitor of histone deacetylase with IC50 values of 0.112 and 433 nM for HDAC2 and HDAC6, respectively [1].
    Histone deacetylases (HDACs) are a series of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone and make the histones to wrap the DNA more tightly, which prevent transcription.
    Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor. Natural and synthetic santacruzamate A inhibited HDAC2 with IC50 values of 119 and 112 pM respectively and inhibited HDAC6 with IC50 values of 434 and 433 nM, respectively. Santacruzamate A was 700-fold more potent than SAHA for HDAC2. However, santacruzamate A inhibited HDAC4 with IC50 values of >1 µM. In HCT-116 colon carcinoma cells, natural and synthetic santacruzamate A inhibited cell growth with GI50 values of 29.4 and 28.3 µM, respectively. In HuT-78 cutaneous T-cell lymphoma cells, both inhibited cell growth with GI50 values of 1.4 and 1.3 µM, respectively [1].
- Properties
  - Alternative Name
    
    ethyl N-[4-oxo-4-(2-phenylethylamino)butyl]carbamate
    
    CAS Number
    
    1477949-42-0
    
    Molecular Formula
    
    C15H22N2O3
    
    Molecular Weight
    
    278.35
    
    Purity
    
    98.48%
    
    Solubility
    
    insoluble in H2O; ≥49.7 mg/mL in EtOH; ≥8.8 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Santacruzamate A (CAY10683)

Santacruzamate A (CAY10683)

Background

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