Name: Sal 003
Price: 277.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Eukaryotic initiation factor 2 α-subunit (eIF2α) plays a critical role in the regulation of protein synthesis. Moreover, it also plays an important role in synaptic plasticity and long-term memory consolidation. Sal003 is a selective inhibitor of eIF2α dephosphorylation.
    In vitro: Sal003 specifically prevents dephosphorylation of eIF2α by blocking eIF2α phosphatases. In Sal003-treated cells polysomes dissociated and consistent with this β-actin mRNA shifted to lighter fractions, reflecting the inhibition of general translation [1].
    In vivo: Intra-basolateral amygdala (BLA) infusions of Sal003 immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced CPP, leading to a long-lasting suppression of drug-paired stimulus-induced craving. Moreover, inhibition of eIF2α dephosphorylation in the BLA immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. These results demonstrate that eIF2α dephosphorylation in the BLA mediates the memory reconsolidation of drug-paired stimuli [1].
    Clinical trials: Currenlty no clinical data are available.
- Properties
  - Alternative Name
    
    (E)-3-phenyl-N-[2,2,2-trichloro-1-[(4-chlorophenyl)carbamothioylamino]ethyl]prop-2-enamide
    
    CAS Number
    
    1164470-53-4
    
    Molecular Formula
    
    C18H15Cl4N3OS
    
    Molecular Weight
    
    463.21
    
    Appearance
    
    A solid
    
    Purity
    
    99.91%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥20.15 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Sal 003

Sal 003

Background

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