Name: Saccharin 1-methylimidazole (SMI)
Price: 273.00 USD

- Overview
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    Background
    
    Saccharin 1-methylimidazole (SMI) is a DNA and RNA synthesis activator.Saccharin 1-methylimidazole (SMI) is the saccharin salt of 1-methylimidazole. 1-Methylimidazole or N-methylimidazole is identified as an aromatic heterocyclic organic agent with the formula CH3C3H3N2. 1-Methylimidazole is a colourless liquid that is used as a base, a specialty solvent, and as a precursor to some ionic liquids. 1-Methylimidazole is a fundamental nitrogen heterocycle and 1-methylimidazole mimics for a variety of nucleoside bases as well as histidine and histamine.In vitro: Saccharin 1-methylimidazole was found to be able to perform very well for DNA and RNA synthesis. In addition, by using 3 minute, 6 minute, and 12 minute coupling times, saccharin 1-methylimidazole was evaluated in RNA synthesis using TBDMS phosphoramidites, and the results found that a 6 minute coupling time for saccharin 1-methylimidazole showed ETT at a 6 minute coupling time. In additio, it was found that longer coupling times for Saccharin 1-methylimidazole could result in even further improvements in RNA coupling efficiencies [1]. In vivo: So far, there is no animal in vivo data reported for saccharin 1-methylimidazole. Clinical trial: Up to now, saccharin 1-methylimidazole is not used clinically.
- Properties
  - Categories
    
    DNA and RNA synthesis activator
    
    Alternative Name
    
    1-methyl-1H-imidazol-1-ium benzo[d]isothiazol-3-olate 1,1-dioxide
    
    CAS Number
    
    482333-74-4
    
    Molecular Formula
    
    C11H11N3O3S
    
    Molecular Weight
    
    265.29
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    [O-]C1=NS(C2=CC=CC=C21)(=O)=O.C[NH+]3C=CN=C3
    
    * For Research Use Only