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Overview
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Background
(S)-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of the inducible nitric oxide synthase (iNOS). Nitric oxide synthases, composed of the constitutive and the inducible isoforms, are a family of enzymes responsible for catalyzing the production of nitric oxide (NO) from L-arginine. The inducible isoform, i.e. iNOS, can be induced in various cells, including macrophages, by a variety of agents such as endotoxin, and thereby produces NO as an immune defense mechanism. Enhanced NO formation has been implied in the pathophysiology of a variety of diseases, such as circulatory shock. Thus, (S)-methylisothiourea sulfate, as a selective iNOS inhibitor, may have considerable value in the therapy of circulatory shock of various etiologies and other pathophysiological conditions associated with induction of iNOS.
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- Properties
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