Name: RMR
Price: 275.00 USD

- Overview
  - Disrupts PAK1 RUNX3 interaction.
    RMR is a peptide derived from the protein sequence flanking the threonine 209 phosphorylation site of the Runt-related transcription factor 3 (RUNX3) protein, chosen based on docking efficiency with the active site of P21 Activated Kinase 1 (PAK1), and ability to displace PAK1 RUNX3 interaction in models. PAK1 is an oncogenic serine/threonine kinase which modulates several signalling pathways involved in cancer, and phosphorylation of RUNX3 at T209 by PAK1 switches the function of RUNX3 from tumour suppressor to oncogene. RMR peptide is stable in vitro and in vivo, non toxic to normal cells, and inhibits threonine 209 phosphorylation in RUNX3 by PAK1. In cell culture models RMR peptide reduces proliferation of human oral squamous cell carcinoma samples, and in vivo causes 33% tumour regression in tumour xenograft models.
    
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    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    RMR peptide
    
    Molecular Formula
    
    C57H101N21O17S
    
    Molecular Weight
    
    1383.74
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Arg-Met-Arg-Val-Thr-Pro-Ser-Thr-Pro-Ser-Pro-Arg-OH,RMRVTPSTPSPR
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

RMR

RMR

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