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Rigosertib sodium salt

Rigosertib sodium salt

Catalog Number:
L002368305APE
Mfr. No.:
APE-A1404
Price:
$354
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      • Overview

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          Background

          Rigosertib (ON-01910,Estybon) is a potent, specific PLK1 inhibitor with IC50 value of 9nM. Rigosertib strongly inhibited the proliferation of cancer cell lines, with observed IC50 values in the nanomolar range for both HeLa (115 nM) and C33A (45 nM) cells. In contrast, rigosertib had a minimal effect on normal cell lines, BJ and Ect1/E6E7 (IC50 > 0.1 mM) [1]
          HeLa and C33A cells demonstrated a complete (>95%) G2/M arrest at concentrations of rigosertib >0.5 μM, whereas at
          Rigosertib has been reported to be a more potent radiosensitizer than cisplatin in vivo [1].

      • Properties
        • Alternative Name
          ON-01910,Estybon; sodium;2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetate
          CAS Number
          1225497-78-8
          Molecular Formula
          C21H24NNaO8S
          Molecular Weight
          473.47
          Appearance
          A solid
          Purity
          98.00%
          Solubility
          ≥23.65 mg/mL in DMSO; insoluble in EtOH; ≥52.3 mg/mL in H2O
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference

        • 1. Costa, D. C. S.; Forezi, L. S. M.; et al. "A Compendium of Tyrosine-kinase Inhibitors: Powerful and Efficient Drugs against Cancer." Rev. Virtual Quim., 2017, 9 (3), 974-1064.

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