Name: Resiquimod (R-848)
Price: 206.00 USD

- Overview
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    Background
    
    Resiquimod (R-848, S-27609) is a modifier of immune response [1].
    Resiquimod (R-848, S-27609) is the analogue of imiquimod (R-837,S-26308). Resiquimod has been reported to dose-dependently induce some cytokines including IFN, TNF, IL-1β and IL-6 in human peripheral blood mononuclear (PBMCs). In addition, Resiquimod has been revealed to stimulate intracellular IL-1βincreased approximately 15%. The results have also been noted that both monocytes and B cells produced IFN in response to Resiquimod. Besides, Resiquimod has determined the induced increases in IFN-α, TNF, and IL-8 mRNA expression in PBMCs when compared with the untreated cell. Moreover, Resiquimod has been found to be an effective antiviral and antitumor agent in animal models [1].
    
    [1] Gibson SJ, Imbertson LM, Wagner TL, Testerman TL, Reiter MJ, Miller RL, Tomai MA.Cellular requirements for cytokine production in response to the immunomodulators imiquimod and S-27609. J Interferon Cytokine Res. 1995 Jun; 15 (6): 537-45.
- Properties
  - Categories
    
    Immune response modifier
    
    Alternative Name
    
    1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
    
    CAS Number
    
    144875-48-9
    
    Molecular Formula
    
    C17H22N4O2
    
    Molecular Weight
    
    314.38
    
    Purity
    
    99.82%
    
    Solubility
    
    insoluble in H2O; ≥12.65 mg/mL in EtOH with ultrasonic; ≥15.85 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N
    
    * For Research Use Only
- Reference
  - 1. Hua Zhang, Wei-Lun Tang, et al. "Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy." J Control Release. 2020 Nov 13;S0168-3659(20)30662-3. PMID:33189786
    2. Mohammed S, Vineetha NS, et al. "Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus." FASEB J. 2019 Jun;33(6):7061-7071. PMID:30840833
    3. Qu S, Qin T, et al. "The effects of resiquimod in an ovalbumin-induced allergic rhinitis model." Int Immunopharmacol. 2018 Jun;59:233-242. PMID:29665497