Recombinant Presenilin 1 Monoclonal Antibody

Recombinant Presenilin 1 Monoclonal Antibody

Catalog Number:
A001512074RED
Mfr. No.:
RD87072A
Price:
$392
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      • Overview
        • Calculated MW: 79kDa
          Observed MW: 79kDa

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          Background

          Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

      • Properties
        • Host
          rabbit
          Antibody Type
          monoclonal
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          A synthetic peptide of human Presenilin 1
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
          Storage
          Store at -20°C Valid for 12 months. Avoid freeze-thaw cycles.
          Concentration
          300 μg/mL
          Antigen
          AD3, FAD, PS-1, PS1, S182, Presenilin 1, PSEN1 (Gene ID:5663; UniProt:P49768)

          * For reference only.

      • Applications
        • Application
          WB
        • Application Dilutions
          WB 1:1000-1:2000

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