Name: Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 11B/Osteoprotegerin/TNFRSF11B (C-10His)
Price: Inquiry

- Overview
  - MW : 45.1kD. Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 11B is produced by our Mammalian expression system and the target gene encoding Glu22-Leu401 is expressed with a 10His tag at the C-terminus. Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG inhibits TRAIL-induced apoptosis. Expression of RANK L on the cell surface, and thus its ability to stimulate osteoclastogenesis, is regulated by OPG by intracellular and extracellular mechanisms. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. It may also play a role in preventing arterial calcification.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    Human cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
    
    Storage
    
    Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    O08712
    
    Gene ID
    
    18383
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 11B/Osteoprotegerin/TNFRSF11B (C-10His)

Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 11B/Osteoprotegerin/TNFRSF11B (C-10His)

More Information

We Also Recommend

Recombinant Human Angiopoietin-related Protein 7/ANGPTL7 (C-10His)

Recombinant Human Receptor Tyrosine-protein Kinase ErbB-4/ErbB4/Her4 (C-6His)

Recombinant Human Serpin A12/Vaspin (C-10His)