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Overview
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MW : 42.3kD. Recombinant Mouse TGF beta receptor II is produced by our Mammalian expression system and the target gene encoding Ile24-Asp159 is expressed with a Fc tag at the C-terminus. Transforming growth factor- beta (TGF- beta) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF- beta regulates cellular processes by binding to three high-affinity cell surface receptors: TGF- beta receptor type I (TGF- beta-RI), TGF- beta receptor type II (TGF- beta-RII), and TGF- beta beta receptor type III (TGF- beta-RIII). TGF- beta RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF- beta) receptor subfamily. TGF- beta RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
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