Recombinant Mouse CD28//TP44 (C-Fc-6His)

Recombinant Mouse CD28//TP44 (C-Fc-6His)

Catalog Number:
P001412276ABE
Mfr. No.:
Abe32-8447
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      • Overview
        • MW : 43kD. Recombinant Mouse CD28 is produced by our Mammalian expression system and the target gene encoding Asn20-Lys149 is expressed with a Fc, 6His tag at the C-terminus. T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

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      • Properties
        • Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
          Storage
          Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

          More Information

          UniProt
          Gene ID
          12487

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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