Recombinant IKB alpha Monoclonal Antibody

Recombinant IKB alpha Monoclonal Antibody

Catalog Number:
A001512013RED
Mfr. No.:
RD86903A
Price:
$392
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      • Overview
        • Calculated MW: 44kDa
          Observed MW: 55kDa

          Please contact us at for specific academic pricing.

          Background

          Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha (NFKBIA,synonyms: IKBA,MAD-3,NFKBI). NFKB1 or NFKB2 is bound to REL,RELA ,or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB),which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA,or IKBKB) marks them for destruction via the ubiquitination pathway,thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.

      • Properties
        • Host
          rabbit
          Antibody Type
          monoclonal
          Isotype
          IgG
          Reactivity
          human; rat
          Immunogen
          A synthetic peptide of human IKB alpha
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
          Storage
          Store at -20°C Valid for 12 months. Avoid freeze-thaw cycles.
          Concentration
          300 μg/mL
          Antigen
          I kappa B alpha, I-kappa-B-alpha, IkappaBalpha, IkB-alpha, IKBA, IKBA, IKBalpha, MAD 3, MAD3, NF kappa B inhibitor alpha, NFKBI, IKB alpha (Gene ID:4792; UniProt:P25963)

          * For reference only.

      • Applications
        • Application
          WB
        • Application Dilutions
          WB 1:1000-1:2000

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