Name: Recombinant Human Vav 1 Guanine Nucleotide Exchange Factor
Price: Inquiry

- Overview
  - VAV1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (189-565a.a) and having a molecular mass of 46.8kDa. VAV1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Vav1 Guanine Nucleotide Exchange Factor (VAV1), belongs to the VAV gene family. The VAV1 proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases whichactivate pathways leading to actin cytoskeletal rearrangements and transcriptionalalterations. VAV1 is essential in hematopoiesis, taking part in T-cell andB-cell development and activation. VAV1 has been identified as the specificbinding partner of Nef proteins from HIV-1. In addition, VAV1 contains an SH2domain, which could show its function as a substrate for tyrosine kinases. Expressionof VAV1 is limited solely to cells of hematopoietic origin, as well as those ofthe erythroid, lymphoid and myeloid lineages. Among the diseases associatedwith VAV1 are cherubism, and hiv-1.
    
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- Properties
  - Protein Name
    
    Vav 1 Guanine Nucleotide Exchange Factor, VAV, Vav 1Oncogene, Proto-Oncogene Vav.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greaterthan 85% as determined by SDS-PAGE.
    
    Formulation
    
    VAV1 protein solution (0.25mg/ml) containing In 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 30% glycerol and 2mM DTT.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Vav 1 Guanine Nucleotide Exchange Factor

Recombinant Human Vav 1 Guanine Nucleotide Exchange Factor

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