Name: Recombinant Human Tyrosine-Protein Kinase Blk/BLK (C-6His)
Price: Inquiry

- Overview
  - MW : 58.7kD. Recombinant Human B Lymphocyte Kinase is produced by our E.coli expression system and the target gene encoding Gly2-Pro505 is expressed with a 6His tag at the C-terminus. Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Supplied as a 0.2 µm filtered solution of 20mM Tris, 500mM NaCl, 1mM DTT, pH 7.4.
    
    Storage
    
    Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    P51451
    
    Gene ID
    
    640
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Tyrosine-Protein Kinase Blk/BLK (C-6His)

Recombinant Human Tyrosine-Protein Kinase Blk/BLK (C-6His)

More Information

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