Name: Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 4 (C-Fc-Avi)
Price: Inquiry

- Overview
  - MW : 48.6kD. Recombinant Human TNF Receptor Superfamily Member 4 is produced by our Mammalian expression system and the target gene encoding Leu29-Ala216 is expressed with a Fc & Avi tag at the C-terminus. OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    Human cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
    
    Storage
    
    Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    P43489
    
    Gene ID
    
    7293
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 4 (C-Fc-Avi)

Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 4 (C-Fc-Avi)

More Information

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