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Overview
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MW : 29.64kD. Recombinant Human Tryptase beta-2 is produced by our Mammalian expression system and the target gene encoding Ala19-Pro275 is expressed with a 6His tag at the C-terminus. Tryptases are Trypsin-like Serine Proteases. beta-Tryptases are the main isoenzymes in mast cells. b tryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, beta-Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, beta-Tryptases are released and participate in provoking inflammatory conditions . beta-Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders.
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