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Overview
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Transferrin receptor protein 1 (TFRC), also known as CD71, is a type 2 transmembrane glycoprotein that belongs to the peptidase M28 family. TFRC is expressed by erythroid progenitors, muscle cells and proliferating cells as a 188 kDa disulfide-linked homodimer of 95 kDa monomers. TFRC plays an essential role in iron delivery from transferrin to cells. It is necessary for the development of erythrocytes and the nervous system. TFRC is a potential new target for human leukemia & lymphoma. The hereditary hemochromatosis protein HFE competes with diferric transferrin for binding to TFRC, and targets TFRC for degradation rather than recycling.
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