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Overview
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CEACAM5, also known as CEA or D66e, is a member of the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed predominantly by epithelial cells. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in various cancers and are associated with adhesion and invasion. CEACAM5 can regulate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a commonly used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been found to contribute to tumorigenicity by inhibiting cellular differentiation. Furthermore, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.
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