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Overview
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TRIP10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 309 amino acids (260-545) and having a molecular mass of 34.6 kDa. TRIP10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Thyroid Hormone Receptor Interactor 10 (TRIP10) is a part of the F-BAR family of proteins which is expressed in a variety of tissues, including kidney, brain, liver, lung, heart and pancreas. The F-BAR family of proteins contains an N-terminal, alpha-helical, region which is hydrophobic and related to the Bin Amphiphysin Rvs (BAR) protein family. TRIP10 is required for the Insulin-dependent translocation of Glut4 to the plasma membrane and is vital for the coordination of membrane tubulation with Actin cytoskeletal reorganization during endocytosis.
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Overview