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Overview
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The protein has a predicted molecular mass of 44.5 kDa after removal of the signal peptide. The apparent molecular mass of TACI-hFc is approximately 33-53 kDa due to glycosylation. The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
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- Properties
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Overview