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Recombinant Human T-cell surface glycoprotein CD4/sCD4 (C-Fc)

Recombinant Human T-cell surface glycoprotein CD4/sCD4 (C-Fc)

Catalog Number:
P001411369ABE
Mfr. No.:
Abe32-9570
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      • Overview

        • CD4 is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. Mature human CD4 consists of a 371-amino acid extracellular region containing four immunoglobulin-like domains, a 22-aa transmembrane segment, and a 40-aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T-cells during their development in the thymus. CD4 binds directly to MHC class-II molecules on antigen presenting cells (10). This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a co-receptor for the gp120 surface glycoprotein of HIV-1.

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      • Properties
        • Protein Name
          T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4; Scd4
          Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 µm filtered solution of PBS, 1mM EDTA, PH7.4.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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